冬凌草甲素抗突变性研究

doi:10.3969/j.issn.1004-616x.2001.01.003

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2001, Vol. 13 ›› Issue (1): 8-009.doi: 10.3969/j.issn.1004-616x.2001.01.003

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STUDY ON THE ANTIMUTAGENICTTY OF ORIDONIN

YANG Sheng - li, HAN Shao - yin, ZHANG Qiao, DING Lan - ping, SONG Ai - yun, GONG Ya - ou, ZHANG Tan - mu

Department of Esophageal Cancer Research, Henan Medical University, Zhengzhou 450052, China

Received:2000-03-27 Revised:2000-05-25 Online:2001-01-30 Published:2001-01-30

Abstract

Abstract: Purpose : To study the antimutagenicity of Oridonin Methods : Ames test and micronucleus assay of polychromatic erythrocytes in mice bone marrow were used. Results : Oridonin could evidently inhibit the reverse mutation on S almonella typhimuriun st rains TA98 and TA100 without S9mix. The rates of maximum inhibition were 89. 1 % and 80. 2 % respectively. In addition , Oridonin could significantly reduce micronucleus requencies induced by cyclophosphamide ( P < 0. 01) . Conclusion : Oridonin has significant antimutagenic effect .

Key words: Oridonin, antimutagenicity, Ames test, micronucleus test

CLC Number:

R73011

YANG Sheng - li, HAN Shao - yin, ZHANG Qiao, DING Lan - ping, SONG Ai - yun, GONG Ya - ou, ZHANG Tan - mu. STUDY ON THE ANTIMUTAGENICTTY OF ORIDONIN[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2001, 13(1): 8-009.

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STUDY ON THE ANTIMUTAGENICTTY OF ORIDONIN

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